About Cyclic AMP-responsive element-binding protein 3-like protein 3
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) is a protein
from Homo sapiens identified by UniProt accession
Q68CJ9, 461 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Cyclic AMP-responsive element-binding protein 3-like protein 3 |
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| UniProt accession | Q68CJ9 |
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| Gene | CREB3L3 |
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| Organism | Homo sapiens |
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| Length | 461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- hypertriglyceridemia 2 · score 0.73
- triglyceride measurement · score 0.58
- lipoprotein measurement · score 0.51
- neurodegenerative disease · score 0.51
- Hyperlipoproteinemia type 4 · score 0.40
- lysosomal storage disease · score 0.39
- Parkinson disease · score 0.39
- multiple sclerosis · score 0.39
- Alzheimer disease · score 0.39
- Hypertriglyceridemia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68CJ9-F1 | alphafold | PREDICTED | 58.94 | — |
Amino-acid sequence (461 residues)
MNTDLAAGKM ASAACSMDPI DSFELLDLLF DRQDGILRHV ELGEGWGHVK DQQVLPNPDS DDFLSSILGS GDSLPSSPLW SPEGSDSGIS EDLPSDPQDT PPRSGPATSP AGCHPAQPGK GPCLSYHPGN SCSTTTPGPV IQVPEASVTI DLEMWSPGGR ICAEKPADPV DLSPRCNLTV KDLLLSGSSG DLQQHHLGAS YLLRPGAGHC QELVLTEDEK KLLAKEGITL PTQLPLTKYE ERVLKKIRRK IRNKQSAQES RKKKKEYIDG LETRMSACTA QNQELQRKVL HLEKQNLSLL EQLKKLQAIV VQSTSKSAQT GTCVAVLLLS FALIILPSIS PFGPNKTESP GDFAPVRVFS RTLHNDAASR VAADAVPGSE APGPRPEADT TREESPGSPG ADWGFQDTAN LTNSTEELDN ATLVLRNATE GLGQVALLDW VAPGPSTGSG RAGLEAAGDE L
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