About Acyl-coenzyme A synthetase ACSM2B, mitochondrial
Acyl-coenzyme A synthetase ACSM2B, mitochondrial (ACSM2B) is a protein
from Homo sapiens identified by UniProt accession
Q68CK6, 577 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Acyl-coenzyme A synthetase ACSM2B, mitochondrial |
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| UniProt accession | Q68CK6 |
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| Gene | ACSM2B |
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| Organism | Homo sapiens |
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| Length | 577 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.46
- sleep duration · score 0.29
- triglyceride measurement · score 0.29
- cutaneous melanoma · score 0.26
- lung adenocarcinoma · score 0.26
- gout · score 0.25
- uric acid measurement · score 0.25
- glioblastoma multiforme · score 0.16
- head and neck squamous cell carcinoma · score 0.15
- squamous cell lung carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68CK6-F1 | alphafold | PREDICTED | 91.41 | — |
Amino-acid sequence (577 residues)
MHWLRKVQGL CTLWGTQMSS RTLYINSRQL VSLQWGHQEV PAKFNFASDV LDHWADMEKA GKRLPSPALW WVNGKGKELM WNFRELSENS QQAANILSGA CGLQRGDRVA VMLPRVPEWW LVILGCIRAG LIFMPGTIQM KSTDILYRLQ MSKAKAIVAG DEVIQEVDTV ASECPSLRIK LLVSEKSCDG WLNFKKLLNE ASTTHHCVET GSQEASAIYF TSGTSGLPKM AEHSYSSLGL KAKMDAGWTG LQASDIMWTI SDTGWILNIL GSLLESWTLG ACTFVHLLPK FDPLVILKTL SSYPIKSMMG APIVYRMLLQ QDLSSYKFPH LQNCLAGGES LLPETLENWR AQTGLDIREF YGQTETGLTC MVSKTMKIKP GYMGTAASCY DVQVIDDKGN VLPPGTEGDI GIRVKPIRPI GIFSGYVENP DKTAANIRGD FWLLGDRGIK DEDGYFQFMG RADDIINSSG YRIGPSEVEN ALMKHPAVVE TAVISSPDPV RGEVVKAFVI LASQFLSHDP EQLTKELQQH VKSVTAPYKY PRKIEFVLNL PKTVTGKIQR TKLRDKEWKM SGKARAQ
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