About Heparan-alpha-glucosaminide N-acetyltransferase
Heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) is a protein
from Homo sapiens identified by UniProt accession
Q68CP4, 663 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Heparan-alpha-glucosaminide N-acetyltransferase |
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| UniProt accession | Q68CP4 |
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| Gene | HGSNAT |
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| Organism | Homo sapiens |
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| Length | 663 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- mucopolysaccharidosis type 3C · score 0.84
- retinitis pigmentosa 73 · score 0.77
- mucopolysaccharidosis type 3 · score 0.72
- Retinal dystrophy · score 0.53
- retinitis pigmentosa · score 0.51
- neurodegenerative disease · score 0.47
- genetic disorder · score 0.47
- synovial plica syndrome · score 0.27
- monocyte count · score 0.24
- eosinophil count · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68CP4-F1 | alphafold | PREDICTED | 79.87 | — |
Amino-acid sequence (663 residues)
MTGARASAAE QRRAGRSGQA RAAERAAGMS GAGRALAALL LAASVLSAAL LAPGGSSGRD AQAAPPRDLD KKRHAELKMD QALLLIHNEL LWTNLTVYWK SECCYHCLFQ VLVNVPQSPK AGKPSAAAAS VSTQHGSILQ LNDTLEEKEV CRLEYRFGEF GNYSLLVKNI HNGVSEIACD LAVNEDPVDS NLPVSIAFLI GLAVIIVISF LRLLLSLDDF NNWISKAISS RETDRLINSE LGSPSRTDPL DGDVQPATWR LSALPPRLRS VDTFRGIALI LMVFVNYGGG KYWYFKHASW NGLTVADLVF PWFVFIMGSS IFLSMTSILQ RGCSKFRLLG KIAWRSFLLI CIGIIIVNPN YCLGPLSWDK VRIPGVLQRL GVTYFVVAVL ELLFAKPVPE HCASERSCLS LRDITSSWPQ WLLILVLEGL WLGLTFLLPV PGCPTGYLGP GGIGDFGKYP NCTGGAAGYI DRLLLGDDHL YQHPSSAVLY HTEVAYDPEG ILGTINSIVM AFLGVQAGKI LLYYKARTKD ILIRFTAWCC ILGLISVALT KVSENEGFIP VNKNLWSLSY VTTLSSFAFF ILLVLYPVVD VKGLWTGTPF FYPGMNSILV YVGHEVFENY FPFQWKLKDN QSHKEHLTQN IVATALWVLI AYILYRKKIF WKI
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