About Glycosyltransferase 8 domain-containing protein 1
Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) is a protein
from Homo sapiens identified by UniProt accession
Q68CQ7, 371 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Glycosyltransferase 8 domain-containing protein 1 |
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| UniProt accession | Q68CQ7 |
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| Gene | GLT8D1 |
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| Organism | Homo sapiens |
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| Length | 371 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (85)
Diseases linked to this target (Open Targets).
- frontotemporal dementia · score 0.26
- familial amyotrophic lateral sclerosis · score 0.19
- amyotrophic lateral sclerosis · score 0.12
- axial length measurement · score 0.09
- schizophrenia · score 0.09
- blood protein measurement · score 0.09
- bipolar disorder · score 0.09
- BMI-adjusted waist circumference · score 0.08
- unipolar depression · score 0.08
- osteoarthritis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68CQ7-F1 | alphafold | PREDICTED | 84.76 | — |
Amino-acid sequence (371 residues)
MSFRKVNIII LVLAVALFLL VLHHNFLSLS SLLRNEVTDS GIVGPQPIDF VPNALRHAVD GRQEEIPVVI AASEDRLGGA IAAINSIQHN TRSNVIFYIV TLNNTADHLR SWLNSDSLKS IRYKIVNFDP KLLEGKVKED PDQGESMKPL TFARFYLPIL VPSAKKAIYM DDDVIVQGDI LALYNTALKP GHAAAFSEDC DSASTKVVIR GAGNQYNYIG YLDYKKERIR KLSMKASTCS FNPGVFVANL TEWKRQNITN QLEKWMKLNV EEGLYSRTLA GSITTPPLLI VFYQQHSTID PMWNVRHLGS SAGKRYSPQF VKAAKLLHWN GHLKPWGRTA SYTDVWEKWY IPDPTGKFNL IRRYTEISNI K
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