Protein sel-1 homolog 3 (SEL1L3)

About Protein sel-1 homolog 3

Protein sel-1 homolog 3 (SEL1L3) is a protein from Homo sapiens identified by UniProt accession Q68CR1, 1132 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Protein sel-1 homolog 3
UniProt accession	Q68CR1
Gene	SEL1L3
Organism	Homo sapiens
Length	1132 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.17
total blood protein measurement · score 0.16
serum albumin measurement · score 0.16
body height · score 0.12
high density lipoprotein cholesterol measurement · score 0.11
metabolite measurement · score 0.10
triglyceride measurement · score 0.10
ringed hair disease · score 0.08
Griscelli syndrome type 3 · score 0.08
uncombable hair syndrome · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q68CR1-F1	alphafold	PREDICTED	81.33	—

Amino-acid sequence (1132 residues)

MQRRGAGLGW PRQQQQQPPP LAVGPRAAAM VPSGGVPQGL GGRSACALLL LCYLNVVPSL GRQTSLTTSV IPKAEQSVAY KDFIYFTVFE GNVRNVSEVS VEYLCSQPCV VNLEAVVSSE FRSSIPVYKK RWKNEKHLHT SRTQIVHVKF PSIMVYRDDY FIRHSISVSA VIVRAWITHK YSGRDWNVKW EENLLHAVAK NYTLLQTIPP FERPFKDHQV CLEWNMGYIW NLRANRIPQC PLENDVVALL GFPYASSGEN TGIVKKFPRF RNRELEATRR QRMDYPVFTV SLWLYLLHYC KANLCGILYF VDSNEMYGTP SVFLTEEGYL HIQMHLVKGE DLAVKTKFII PLKEWFRLDI SFNGGQIVVT TSIGQDLKSY HNQTISFRED FHYNDTAGYF IIGGSRYVAG IEGFFGPLKY YRLRSLHPAQ IFNPLLEKQL AEQIKLYYER CAEVQEIVSV YASAAKHGGE RQEACHLHNS YLDLQRRYGR PSMCRAFPWE KELKDKHPSL FQALLEMDLL TVPRNQNESV SEIGGKIFEK AVKRLSSIDG LHQISSIVPF LTDSSCCGYH KASYYLAVFY ETGLNVPRDQ LQGMLYSLVG GQGSERLSSM NLGYKHYQGI DNYPLDWELS YAYYSNIATK TPLDQHTLQG DQAYVETIRL KDDEILKVQT KEDGDVFMWL KHEATRGNAA AQQRLAQMLF WGQQGVAKNP EAAIEWYAKG ALETEDPALI YDYAIVLFKG QGVKKNRRLA LELMKKAASK GLHQAVNGLG WYYHKFKKNY AKAAKYWLKA EEMGNPDASY NLGVLHLDGI FPGVPGRNQT LAGEYFHKAA QGGHMEGTLW CSLYYITGNL ETFPRDPEKA VVWAKHVAEK NGYLGHVIRK GLNAYLEGSW HEALLYYVLA AETGIEVSQT NLAHICEERP DLARRYLGVN CVWRYYNFSV FQIDAPSFAY LKMGDLYYYG HQNQSQDLEL SVQMYAQAAL DGDSQGFFNL ALLIEEGTII PHHILDFLEI DSTLHSNNIS ILQELYERCW SHSNEESFSP CSLAWLYLHL RLLWGAILHS ALIYFLGTFL LSILIAWTVQ YFQSVSASDP PPRPSQASPD TATSTASPAV TPAADASDQD QPTVTNNPEP RG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards