DENN domain-containing protein 2C (DENND2C)

About DENN domain-containing protein 2C

DENN domain-containing protein 2C (DENND2C) is a protein from Homo sapiens identified by UniProt accession Q68D51, 928 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	DENN domain-containing protein 2C
UniProt accession	Q68D51
Gene	DENND2C
Organism	Homo sapiens
Length	928 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

platelet component distribution width · score 0.58
mean platelet volume · score 0.58
platelet count · score 0.22
leukocyte count · score 0.13
myeloid white cell count · score 0.06
metabolite measurement · score 0.04
esophageal adenocarcinoma · score 0.03
Barrett's esophagus · score 0.03
autism · score 0.02
creatinine measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q68D51-F1	alphafold	PREDICTED	61.34	—

Amino-acid sequence (928 residues)

MDVGFSRTTV QTLSRSHCKN IKQKISQWEG RANGISNPEK WCPKDFGVRY NCHQEIRLKK NPIAERKSKN LDVTSRENVG LDINENTKSH DQSENENKKH EYDDTHFFKN ESESNWVCSR VKEIESCKED VLDPETSLPP GNFYTSQILW KKIEALPPDK LLNLALEHCD SSEKELNFRV LDSSYGITKS LENIYSEPEG QECGPSINPL PKPRRTFRYL SESGVTPYKE RNCDKKYCEN NSCAQSSLAS SQEPEPKKYG GKIRGRSKRK SFEFEDIQHF RNRNSQTIRE ELGRNSGSAL YYTQSEDNIY EDIIYPTKEN PYEDIPVQPL PMWRSPSAWK LPPAKSAFKA PKLPPKPQFL HRKTMEVKNS QAYLRSKLTK DTTLPVTLTE WKLFRAGEVA NTKRKNLPRL VLKIDDIFES KRGKKKVKLH SYTGKELPPT KGETSGNESD AEYLPKNRHK RLAQLQPSSK RNPHYQTLER DLIELQEQQL FELFVVVSLQ KKPSGISYIP QVIQQFPGKD DHGYKQSKDM EERLKVIPKF CFPDSKDWMP TSELKSETFS FVLTGEDGSR WFGYCKKLLP VGKGKRLPEV YCMVSRLGCF NLFSKILDEV EKRREMSPAL VYPFMRSVME APFPAPGRTI TVKSYLPGAG DESIELCRPL DSRLEHVDFK CLFKCLSVCH LIRVCASLLL ERRVIFVANS LSTLSKCGHA VVATLYPFTW QHTYIPVLPA SMIDIVCSPT PFLIGILSCS LPQLQDLPIE EVLIVDLCAD KFLQEVSDED EILPPKLQAA LMQILEERNE ILTQEQNFSQ DVTLNSLVSE AFVRFFVELV GHYSLNMTVT ERGERVFQRE PFRKSHTSRS VRHFLDLFME TQMFAGFIQD RELRKSGVKG LFEIRAIQYL ETIPESEPSG MNRILRSLGS KMKFLQKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards