About Natural cytotoxicity triggering receptor 3 ligand 1
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1) is a protein
from Homo sapiens identified by UniProt accession
Q68D85, 454 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Natural cytotoxicity triggering receptor 3 ligand 1 |
|---|
| UniProt accession | Q68D85 |
|---|
| Gene | NCR3LG1 |
|---|
| Organism | Homo sapiens |
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| Length | 454 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- body mass index · score 0.42
- type 2 diabetes mellitus · score 0.40
- systolic blood pressure · score 0.39
- BMI-adjusted waist circumference · score 0.32
- pulse pressure measurement · score 0.31
- hypertension · score 0.27
- alcohol drinking · score 0.25
- BMI-adjusted waist-hip ratio · score 0.23
- blood pressure · score 0.20
- sex hormone-binding globulin measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68D85-F1 | alphafold | PREDICTED | 77.64 | — |
Amino-acid sequence (454 residues)
MTWRAAASTC AALLILLWAL TTEGDLKVEM MAGGTQITPL NDNVTIFCNI FYSQPLNITS MGITWFWKSL TFDKEVKVFE FFGDHQEAFR PGAIVSPWRL KSGDASLRLP GIQLEEAGEY RCEVVVTPLK AQGTVQLEVV ASPASRLLLD QVGMKENEDK YMCESSGFYP EAINITWEKQ TQKFPHPIEI SEDVITGPTI KNMDGTFNVT SCLKLNSSQE DPGTVYQCVV RHASLHTPLR SNFTLTAARH SLSETEKTDN FSIHWWPISF IGVGLVLLIV LIPWKKICNK SSSAYTPLKC ILKHWNSFDT QTLKKEHLIF FCTRAWPSYQ LQDGEAWPPE GSVNINTIQQ LDVFCRQEGK WSEVPYVQAF FALRDNPDLC QCCRIDPALL TVTSGKSIDD NSTKSEKQTP REHSDAVPDA PILPVSPIWE PPPATTSTTP VLSSQPPTLL LPLQ
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