Acyl-coenzyme A thioesterase MBLAC2 (MBLAC2)

About Acyl-coenzyme A thioesterase MBLAC2

Acyl-coenzyme A thioesterase MBLAC2 (MBLAC2) is a protein from Homo sapiens identified by UniProt accession Q68D91, 279 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Acyl-coenzyme A thioesterase MBLAC2
UniProt accession	Q68D91
Gene	MBLAC2
Organism	Homo sapiens
Length	279 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
self reported educational attainment · score 0.11
intelligence · score 0.11
insulin like growth factor measurement · score 0.08
schizophrenia · score 0.08
IGF-1 measurement · score 0.08
diastolic blood pressure · score 0.08
refractive error · score 0.07
white matter microstructure measurement · score 0.07
Snoring · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q68D91-F1	alphafold	PREDICTED	94.37	—

Amino-acid sequence (279 residues)

MSALEWYAHK SLGDGIFWIQ ERFYESGNRA NIWLVRGSEQ DVVIDTGLGL RSLPEYLYSS GLLQDREAKE DAARRPLLAV ATHVHFDHSG GLYQFDRVAV HHAEAEALAR GDNFETVTWL SDSEVVRTPS PGWRARQFRV QAVQPTLILQ DGDVINLGDR QLTVMHMPGH SRGSICLHDK DRKILFSGDV VYDGSLIDWL PYSRISDYVG TCERLIELVD RGLVEKVLPG HFNTFGAERL FRLASNYISK AGICHKVSTF AMRSLASLAL RVTNSRTSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards