About Ankyrin repeat and SAM domain-containing protein 6
Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) is a protein
from Homo sapiens identified by UniProt accession
Q68DC2, 871 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Ankyrin repeat and SAM domain-containing protein 6 |
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| UniProt accession | Q68DC2 |
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| Gene | ANKS6 |
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| Organism | Homo sapiens |
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| Length | 871 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (130)
Diseases linked to this target (Open Targets).
- nephronophthisis 16 · score 0.78
- nephronophthisis · score 0.38
- Nephronophthisis · score 0.37
- Juvenile nephronophthisis · score 0.37
- Infantile nephronophthisis · score 0.37
- body mass index · score 0.29
- genetic disorder · score 0.19
- cortical surface area measurement · score 0.14
- brain measurement · score 0.14
- cortical thickness · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68DC2-F1 | alphafold | PREDICTED | 59.88 | — |
Amino-acid sequence (871 residues)
MGEGGLPPAF QLLLRACDQG DTETARRLLE PGAAEPAERG AEPEAGAEPA GAEVAGPGAA AAGAVGAPVP VDCSDEAGNT ALQFAAAGGH EPLVRFLLRR GASVNSRNHY GWSALMQAAR FGHVSVAHLL LDHGADVNAQ NRLGASVLTV ASRGGHLGVV KLLLEAGAFV DHHHPSGEQL GLGGSRDEPL DITALMAAIQ HGHEAVVRLL MEWGADPNHA ARTVGWSPLM LAALTGRLGV AQQLVEKGAN PDHLSVLEKT AFEVALDCKH RDLVDYLDPL TTVRPKTDEE KRRPDIFHAL KMGNFQLVKE IADEDPSHVN LVNGDGATPL MLAAVTGQLA LVQLLVERHA DVDKQDSVHG WTALMQATYH GNKEIVKYLL NQGADVTLRA KNGYTAFDLV MLLNDPDTEL VRLLASVCMQ VNKDKGRPSH QPPLPHSKVR QPWSIPVLPD DKGGLKSWWN RMSNRFRKLK LMQTLPRGLS SNQPLPFSDE PEPALDSTMR AAPQDKTSRS ALPDAAPVTK DNGPGSTRGE KEDTLLTTML RNGAPLTRLP SDKLKAVIPP FLPPSSFELW SSDRSRTRHN GKADPMKTAL PQRASRGHPV GGGGTDTTPV RPVKFPSLPR SPASSANSGN FNHSPHSSGG SSGVGVSRHG GELLNRSGGS IDNVLSQIAA QRKKAAGLLE QKPSHRSSPV GPAPGSSPSE LPASPAGGSA PVGKKLETSK RPPSGTSTTS KSTSPTLTPS PSPKGHTAES SVSSSSSHRQ SKSSGGSSSG TITDEDELTG ILKKLSLEKY QPIFEEQEVD MEAFLTLTDG DLKELGIKTD GSRQQILAAI SELNAGKGRE RQILQETIHN FHSSFESSAS NTRAPGNSPC A
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