About G-protein coupled receptor-associated protein LMBRD2
G-protein coupled receptor-associated protein LMBRD2 (LMBRD2) is a protein
from Homo sapiens identified by UniProt accession
Q68DH5, 695 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | G-protein coupled receptor-associated protein LMBRD2 |
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| UniProt accession | Q68DH5 |
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| Gene | LMBRD2 |
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| Organism | Homo sapiens |
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| Length | 695 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- Global developmental delay · score 0.46
- Microcephaly · score 0.46
- Intellectual disability · score 0.46
- Seizure · score 0.46
- microcephaly · score 0.46
- Abnormality of the eye · score 0.46
- Red cell distribution width · score 0.39
- complex neurodevelopmental disorder · score 0.37
- Neurodevelopmental disorder · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68DH5-F1 | alphafold | PREDICTED | 76.75 | — |
Amino-acid sequence (695 residues)
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF ILPLDVSTTI YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS YIPDGIMPIF WRVVYWTSQF LTWILLPFMQ SYARSGGFSI TGKIKTALIE NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN QLQTIGIAAA NTWGLFLLVL LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA EENLEDAMEE VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ FVHTFQSPEP ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV VWSECTFFST TPVLSLFAVF IQLAEKTYNY IYIEIACFLS IFFLSICVYS TVFRIRVFNY YYLASHHQTD AYSLLFSGML FCRLTPPLCL NFLGLTHMDS SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL CIATYFSLGT RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE LLQDAEPLDF NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV
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