About Male-specific lethal 1 homolog
Male-specific lethal 1 homolog (MSL1) is a protein
from Homo sapiens identified by UniProt accession
Q68DK7, 614 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Male-specific lethal 1 homolog |
|---|
| UniProt accession | Q68DK7 |
|---|
| Gene | MSL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 614 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- FEV/FVC ratio · score 0.21
- body height · score 0.19
- hair color · score 0.13
- hair colour measurement · score 0.13
- mathematical ability · score 0.11
- self reported educational attainment · score 0.11
- body weight · score 0.09
- neutrophil count · score 0.09
- mean corpuscular hemoglobin · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68DK7-F1 | alphafold | PREDICTED | 57.56 | — |
Amino-acid sequence (614 residues)
MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDEPGA AEAHFLPRHR KLKEPGPPLA SSQGGSPAPS PAGCGGKGRG LLLPAGAAPG QQEESWGGSV PLPCPPPATK QAGIGGEPAA AGAGCSPRPK YQAVLPIQTG SLVAAAKEPT PWAGDKGGAA SPAATASDPA GPPPLPLPGP PPLAPTATAG TLAASEGRWK SMRKSPLGGG GGSGASSQAA CLKQILLLQL DLIEQQQQQL QAKEKEIEEL KSERDTLLAR IERMERRMQL VKKDNEKERH KLFQGYETEE REETELSEKI KLECQPELSE TSQTLPPKPF SCGRSGKGHK RKSPFGSTER KTPVKKLAPE FSKVKTKTPK HSPIKEEPCG SLSETVCKRE LRSQETPEKP RSSVDTPPRL STPQKGPSTH PKEKAFSSEI EDLPYLSTTE MYLCRWHQPP PSPLPLRESS PKKEETVARC LMPSSVAGET SVLAVPSWRD HSVEPLRDPN PSDLLENLDD SVFSKRHAKL ELDEKRRKRW DIQRIREQRI LQRLQLRMYK KKGIQESEPE VTSFFPEPDD VESLMITPFL PVVAFGRPLP KLTPQNFELP WLDERSRCRL EIQKKQTPHR TCRK
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