BTB/POZ domain-containing protein KCTD16 (KCTD16)

About BTB/POZ domain-containing protein KCTD16

BTB/POZ domain-containing protein KCTD16 (KCTD16) is a protein from Homo sapiens identified by UniProt accession Q68DU8, 428 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein KCTD16
UniProt accession	Q68DU8
Gene	KCTD16
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

daytime rest measurement · score 0.32
Abnormality of refraction · score 0.30
alcohol use disorder measurement · score 0.27
longitudinal alcohol consumption measurement · score 0.27
vitamin D measurement · score 0.25
self reported educational attainment · score 0.24
drug use measurement · score 0.23
alcohol consumption measurement · score 0.15
autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.14
dislocation · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q68DU8-F1	alphafold	PREDICTED	69.04	—

Amino-acid sequence (428 residues)

MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL LWKMFSPKRD TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF PEKGRLKREA EYFQLPDLVK LLTPDEIKQS PDEFCHSDFE DASQGSDTRI CPPSSLLPAD RKWGFITVGY RGSCTLGREG QADAKFRRVP RILVCGRISL AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML SECGFHMVAC NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP VQLIQQSEMR RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ DFLKIKIPDR FPERKHPWQS ELLRKYHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards