About E3 ubiquitin-protein ligase RNF43
E3 ubiquitin-protein ligase RNF43 (RNF43) is a protein
from Homo sapiens identified by UniProt accession
Q68DV7, 783 residues long.
MolForge cross-references it against 0 known binders and
359 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF43 |
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| UniProt accession | Q68DV7 |
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| Gene | RNF43 |
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| Organism | Homo sapiens |
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| Length | 783 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (359)
Diseases linked to this target (Open Targets).
- sessile serrated polyposis cancer syndrome · score 0.67
- pancreatic adenocarcinoma · score 0.53
- gastric adenocarcinoma · score 0.46
- pancreatic carcinoma · score 0.44
- colorectal adenocarcinoma · score 0.44
- pancreatic neoplasm · score 0.39
- hyperplastic polyposis syndrome · score 0.38
- gastric carcinoma · score 0.37
- lung carcinoma · score 0.37
- ovarian mucinous adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68DV7-F1 | alphafold | PREDICTED | 55.51 | — |
Amino-acid sequence (783 residues)
MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL SLASKARMAG ERGASAVLFD ITEDRAAAEQ LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ KAHVRIELKE PPAWPDYDVW ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI SQLATRRYQA SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH YHLPAAYLLG PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG EQQRLAGAQH PYAQGWGLSH LQSTSQHPAA CPVPLRRARP PDSSGSGESY CTERSGYLAD GPASDSSSGP CHGSSSDSVV NCTDISLQGV HGSSSTFCSS LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG ETQVSSHVHY HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR HPQRKRRGGP SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI CGPPGLDKRL LPETPGPCYS NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD TAEGRPCPYP HCQVLSAQPG SEEELEELCE QAV
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