About Microtubule-associated tyrosine carboxypeptidase 1
Microtubule-associated tyrosine carboxypeptidase 1 (MATCAP1) is a protein
from Homo sapiens identified by UniProt accession
Q68EN5, 471 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Microtubule-associated tyrosine carboxypeptidase 1 |
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| UniProt accession | Q68EN5 |
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| Gene | MATCAP1 |
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| Organism | Homo sapiens |
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| Length | 471 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.16
- bone quantitative ultrasound measurement · score 0.13
- heel bone mineral density · score 0.12
- bone density · score 0.10
- mean corpuscular hemoglobin concentration · score 0.10
- high density lipoprotein cholesterol measurement · score 0.08
- monocyte count · score 0.07
- Red cell distribution width · score 0.06
- appendicular lean mass · score 0.05
- sitting height measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q68EN5-F1 | alphafold | PREDICTED | 76.59 | — |
Amino-acid sequence (471 residues)
MVLDSGAQAY DQAPPSPPTS PPSLRHRLKP SDRDGPPLYP WSQSLALPLA LAVPPALQPQ PEQQPFSQML LGHRGHMRRS ESTYSVNSTG RRGRGTLGRP PPGRGRNPGG GTLRPAASLP HIAKTQRDAG HIASKSPCML VALRPTNMDR ERDKFFQSHY TYNPQFEYQE PMPTAVLEKY CEASGQFIHQ AVGIIEAVLE KFGTYEHFEA ATGGQLLTKC QIWSIVRKYM QKEGCAGEVV VQLSEDLLSQ AVMMVENSRP TLAINLTGAR QYWLEGMLRH EIGTHYLRGV NNARQPWHNA EGRLRYGLRP ANPTEEGLAS LHSVLFRKQP FLWRAALLYY TIHRAARMSF RQLFQDLERY VQDADVRWEY CVRAKRGQTD TSLPGCFSKD QVYLDGIVRI LRHRQTIDFP LLTSLGKVSY EDVDHLRPHG VLDNTRVPHF MQDLARYRQQ LEHIMATNRL DEAELGRLLP D
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