LIM/homeobox protein Lhx8 (LHX8)

About LIM/homeobox protein Lhx8

LIM/homeobox protein Lhx8 (LHX8) is a protein from Homo sapiens identified by UniProt accession Q68G74, 356 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	LIM/homeobox protein Lhx8
UniProt accession	Q68G74
Gene	LHX8
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

skin aging measurement · score 0.27
self reported educational attainment · score 0.25
facial morphology measurement · score 0.16
skin aging · score 0.13
age at first sexual intercourse measurement · score 0.07
primary ovarian insufficiency · score 0.07
46,XX gonadal dysgenesis · score 0.07
wheezing · score 0.06
Testicular regression syndrome · score 0.06
46,XX testicular disorder of sex development · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q68G74-F1	alphafold	PREDICTED	67.96	—

Amino-acid sequence (356 residues)

MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS APLSPSSSPR SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLDNLKRE VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ LPISHT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards