About Sodium-dependent neutral amino acid transporter B(0)AT1
Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19) is a protein
from Homo sapiens identified by UniProt accession
Q695T7, 634 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Sodium-dependent neutral amino acid transporter B(0)AT1 |
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| UniProt accession | Q695T7 |
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| Gene | SLC6A19 |
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| Organism | Homo sapiens |
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| Length | 634 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (111)
Diseases linked to this target (Open Targets).
- Hartnup disease · score 0.84
- iminoglycinuria · score 0.70
- Hyperglycinuria · score 0.61
- creatinine measurement · score 0.58
- cystatin C measurement · score 0.50
- Red cell distribution width · score 0.33
- urinary metabolite measurement · score 0.32
- protein measurement · score 0.28
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q695T7-F1 | alphafold | PREDICTED | 89.98 | — |
Amino-acid sequence (634 residues)
MVRLVLPNPG LDARIPSLAE LETIEQEEAS SRPKWDNKAQ YMLTCLGFCV GLGNVWRFPY LCQSHGGGAF MIPFLILLVL EGIPLLYLEF AIGQRLRRGS LGVWSSIHPA LKGLGLASML TSFMVGLYYN TIISWIMWYL FNSFQEPLPW SDCPLNENQT GYVDECARSS PVDYFWYRET LNISTSISDS GSIQWWMLLC LACAWSVLYM CTIRGIETTG KAVYITSTLP YVVLTIFLIR GLTLKGATNG IVFLFTPNVT ELAQPDTWLD AGAQVFFSFS LAFGGLISFS SYNSVHNNCE KDSVIVSIIN GFTSVYVAIV VYSVIGFRAT QRYDDCFSTN ILTLINGFDL PEGNVTQENF VDMQQRCNAS DPAAYAQLVF QTCDINAFLS EAVEGTGLAF IVFTEAITKM PLSPLWSVLF FIMLFCLGLS SMFGNMEGVV VPLQDLRVIP PKWPKEVLTG LICLGTFLIG FIFTLNSGQY WLSLLDSYAG SIPLLIIAFC EMFSVVYVYG VDRFNKDIEF MIGHKPNIFW QVTWRVVSPL LMLIIFLFFF VVEVSQELTY SIWDPGYEEF PKSQKISYPN WVYVVVVIVA GVPSLTIPGY AIYKLIRNHC QKPGDHQGLV STLSTASMNG DLKY
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