About Protein virilizer homolog
Protein virilizer homolog (VIRMA) is a protein
from Homo sapiens identified by UniProt accession
Q69YN4, 1812 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Protein virilizer homolog |
|---|
| UniProt accession | Q69YN4 |
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| Gene | VIRMA |
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| Organism | Homo sapiens |
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| Length | 1812 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- body mass index · score 0.30
- lean body mass · score 0.28
- self reported educational attainment · score 0.25
- body weight · score 0.24
- total blood protein measurement · score 0.23
- fat body mass · score 0.19
- serum non-albumin protein measurement · score 0.19
- blood protein measurement · score 0.18
- smoking behaviour measurement · score 0.18
- cleft lip · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q69YN4-F1 | alphafold | PREDICTED | 69.86 | — |
Amino-acid sequence (1812 residues)
MAVDSAMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH SSLPDNRAYG ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF RPNSKVNTDG LVLRGWYNCL TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ PQPSLKRNPK HADGEKEDQF NGSPPRPQPR GPRTPPGPPP PDDDEDDPVP LPVSGDKEED APHREDYFEP ISPDRNSVPQ EGQYSDEGEV EEEQQEEGEE DEDDVDVEEE EDEDEDDRRT VDSIPEEEEE DEEEEGEEDE EGEGDDGYEQ ISSDEDGIAD LERETFKYPN FDVEYTAEDL ASVPPMTYDP YDRELVPLLY FSCPYKTTFE IEISRMKDQG PDKENSGAIE ASVKLTELLD LYREDRGAKW VTALEEIPSL IIKGLSYLQL KNTKQDSLGQ LVDWTMQALN LQVALRQPIA LNVRQLKAGT KLVSSLAECG AQGVTGLLQA GVISGLFELL FADHVSSSLK LNAFKALDSV ISMTEGMEAF LRGRQNEKSG YQKLLELILL DQTVRVVTAG SAILQKCHFY EVLSEIKRLG DHLAEKTSSL PNHSEPDHDT DAGLERTNPE YENEVEASMD MDLLESSNIS EGEIERLINL LEEVFHLMET APHTMIQQPV KSFPTMARIT GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPVTSAHPGV LQATKDVLKF LAQSQKGLLF FMSEYEATNL LIRALCHFYD QDEEEGLQSD GVIDDAFALW LQDSTQTLQC ITELFSHFQR CTASEETDHS DLLGTLHNLY LITFNPVGRS AVGHVFSLEK NLQSLITLME YYSKEALGDS KSKKSVAYNY ACILILVVVQ SSSDVQMLEQ HAASLLKLCK ADENNAKLQE LGKWLEPLKN LRFEINCIPN LIEYVKQNID NLMTPEGVGL TTALRVLCNV ACPPPPVEGQ QKDLKWNLAV IQLFSAEGMD TFIRVLQKLN SILTQPWRLH VNMGTTLHRV TTISMARCTL TLLKTMLTEL LRGGSFEFKD MRVPSALVTL HMLLCSIPLS GRLDSDEQKI QNDIIDILLT FTQGVNEKLT ISEETLANNT WSLMLKEVLS SILKVPEGFF SGLILLSELL PLPLPMQTTQ VIEPHDISVA LNTRKLWSMH LHVQAKLLQE IVRSFSGTTC QPIQHMLRRI CVQLCDLASP TALLIMRTVL DLIVEDLQST SEDKEKQYTS QTTRLLALLD ALASHKACKL AILHLINGTI KGDERYAEIF QDLLALVRSP GDSVIRQQCV EYVTSILQSL CDQDIALILP SSSEGSISEL EQLSNSLPNK ELMTSICDCL LATLANSESS YNCLLTCVRT MMFLAEHDYG LFHLKSSLRK NSSALHSLLK RVVSTFSKDT GELASSFLEF MRQILNSDTI GCCGDDNGLM EVEGAHTSRT MSINAAELKQ LLQSKEESPE NLFLELEKLV LEHSKDDDNL DSLLDSVVGL KQMLESSGDP LPLSDQDVEP VLSAPESLQN LFNNRTAYVL ADVMDDQLKS MWFTPFQAEE IDTDLDLVKV DLIELSEKCC SDFDLHSELE RSFLSEPSSP GRTKTTKGFK LGKHKHETFI TSSGKSEYIE PAKRAHVVPP PRGRGRGGFG QGIRPHDIFR QRKQNTSRPP SMHVDDFVAA ESKEVVPQDG IPPPKRPLKV SQKISSRGGF SGNRGGRGAF HSQNRFFTPP ASKGNYSRRE GTRGSSWSAQ NTPRGNYNES RGGQSNFNRG PLPPLRPLSS TGYRPSPRDR ASRGRGGLGP SWASANSGSG GSRGKFVSGG SGRGRHVRSF TR
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