Keratin, type I cytoskeletal 40 (KRT40)

About Keratin, type I cytoskeletal 40

Keratin, type I cytoskeletal 40 (KRT40) is a protein from Homo sapiens identified by UniProt accession Q6A162, 431 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 40
UniProt accession	Q6A162
Gene	KRT40
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.19
head and neck squamous cell carcinoma · score 0.18
esophageal cancer · score 0.14
gonorrhea · score 0.02
neoplasm · score 0.01
type 2 diabetes mellitus · score 0.00
hepatocellular carcinoma · score 0.00
heart disease · score 0.00
progeria · score 0.00
neuroendocrine neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6A162-F1	alphafold	PREDICTED	76.11	—

Amino-acid sequence (431 residues)

MTSDCSSTHC SPESCGTASG CAPASSCSVE TACLPGTCAT SRCQTPSFLS RSRGLTGCLL PCYFTGSCNS PCLVGNCAWC EDGVFTSNEK ETMQFLNDRL ASYLEKVRSL EETNAELESR IQEQCEQDIP MVCPDYQRYF NTIEDLQQKI LCTKAENSRL AVQLDNCKLA TDDFKSKYES ELSLRQLLEA DISSLHGILE ELTLCKSDLE AHVESLKEDL LCLKKNHEEE VNLLREQLGD RLSVELDTAP TLDLNRVLDE MRCQCETVLA NNRREAEEWL AVQTEELNQQ QLSSAEQLQG CQMEILELKR TASALEIELQ AQQSLTESLE CTVAETEAQY SSQLAQIQCL IDNLENQLAE IRCDLERQNQ EYQVLLDVKA RLEGEINTYW GLLDSEDSRL SCSPCSTTCT SSNTCEPCSA YVICTVENCC L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards