About Zinc finger protein 518A
Zinc finger protein 518A (ZNF518A) is a protein
from Homo sapiens identified by UniProt accession
Q6AHZ1, 1483 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Zinc finger protein 518A |
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| UniProt accession | Q6AHZ1 |
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| Gene | ZNF518A |
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| Organism | Homo sapiens |
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| Length | 1483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- body height · score 0.28
- mean corpuscular volume · score 0.25
- mean corpuscular hemoglobin concentration · score 0.19
- age at menopause · score 0.19
- smoking status measurement · score 0.17
- age at menarche · score 0.17
- sex hormone-binding globulin measurement · score 0.16
- age at first sexual intercourse measurement · score 0.14
- antisocial behaviour measurement · score 0.09
- attention deficit hyperactivity disorder · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6AHZ1-F1 | alphafold | PREDICTED | 40.45 | — |
Amino-acid sequence (1483 residues)
MPSEQKQLFC DEKQTTLKKD YDVKNEIVDR SAPKPKISGS IHYALKNVKI DLPKINIPNE VLLKHEVDKY RKLFQSKQQT ARKSISIKTV SCVEECTLLH KSERAEEEGV KMSAKILNFS CLKCRDNTRY SPNDLQKHFQ MWHHGELPSY PCEMCNFSAN DFQVFKQHRR THRSTLVKCD ICNNESVYTL LNLTKHFTST HCVNGNFQCE KCKFSTQDVG TFVQHIHRHN EIHYKCGKCH HVCFTKGELQ KHLHIHSGTF PFTCQYCSYG ATRREHLVRH VITLHKEHLY AKEKLEKDKY EKRMAKTSAG LKLILKRYKI GASRKTFWKR KKINSGSDRS IEKNTQVLKK MNKTQTKSED QSHVVQEHLS EEKDERLHCE NNDKAPESES EKPTPLSTGQ GNRAEEGPNA SSGFMKTAVL GPTLKNVMMK NNKLAVSPNY NATFMGFKMM DGKQHIVLKL VPIKQNVCSP GSQSGAAKDG TANLQPQTLD TNGFLTGVTT ELNDTVYMKA ATPFSCSSSI LSGKASSEKE MTLISQRNNM LQTMDYEKSV SSLSATSELV TASVNLTTKF ETRDNVDFWG NHLTQSHPEV LGTTIKSPDK VNCVAKPNAY NSGDMHNYCI NYGNCELPVE SSNQGSLPFH NYSKVNNSNK RRRFSGTAVY ENPQRESSSS KTVVQQPISE SFLSLVRQES SKPDSLLASI SLLNDKDGTL KAKSEIEEQY VLEKGQNIDG QNLYSNENQN LECATEKSKW EDFSNVDSPM MPRITSVFSL QSQQASEFLP PEVNQLLQDV LKIKPDVKQD SSNTPNKGLP LHCDQSFQKH EREGKIVESS KDFKVQGIFP VPPGSVGINV PTNDLNLKFG KEKQVSSIPQ DVRDSEKMPR ISGFGTLLKT QSDAIITQQL VKDKLRATTQ NLGSFYMQSP LLNSEQKKTI IVQTSKGFLI PLNITNKPGL PVIPGNALPL VNSQGIPASL FVNKKPGMVL TLNNGKLEGV SAVKTEGAPA RGTVTKEPCK TPILKVEPNN NCLTPGLCSS IGSCLSMKSS SENTLPLKGP YILKPTSSVK AVLIPNMLSE QQSTKLNISD SVKQQNEIFP KPPLYTFLPD GKQAVFLKCV MPNKTELLKP KLVQNSTYQN IQPKKPEGTP QRILLKIFNP VLNVTAANNL SVSNSASSLQ KDNVPSNQII GGEQKEPESR DALPFLLDDL MPANEIVITS TATCPESSEE PICVSDCSES RVLRCKTNCR IERNFNRKKT SKKIFSKTKT HGSKDSETAF VSRNRNCKRK CRDSYQEPPR RKATLHRKCK EKAKPEDVRE TFGFSRPRLS KDSIRTLRLF PFSSKQLVKC PRRNQPVVVL NHPDADAPEV VSVMKTIAKF NGHVLKVSLS KRTINALLKP VCYNPPKTTY DDFSKRHKTF KPVSSVKERF VLKLTLKKTS KNNYQIVKTT SENILKAKFN CWFCGRVFDN QDTWAGHGQR HLMEATRDWN MLE
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