About HEAT repeat-containing protein 6
HEAT repeat-containing protein 6 (HEATR6) is a protein
from Homo sapiens identified by UniProt accession
Q6AI08, 1181 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | HEAT repeat-containing protein 6 |
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| UniProt accession | Q6AI08 |
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| Gene | HEATR6 |
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| Organism | Homo sapiens |
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| Length | 1181 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.40
- neurodegenerative disease · score 0.26
- mean platelet volume · score 0.20
- bone density · score 0.17
- urate measurement · score 0.17
- sum of eosinophil and basophil counts · score 0.03
- eosinophil count · score 0.03
- allergic rhinitis · score 0.01
- breast cancer · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6AI08-F1 | alphafold | PREDICTED | 80.15 | — |
Amino-acid sequence (1181 residues)
MAAVQVVGSW PSVQPREAPR EAIPERGNGF RLLSARLCAL RPDDSSSART EIHLLFDQLI SENYSEGSGV APEDVSALLV QACRLVPLNQ NHLVSKVSQL IHHLLNRLQV IVDEQHLDFL LAYTISAIHQ CSSWTHREIL QALAALVYCN GSKCQKYLPE LLGNTGLLMK LSDLAQSDPE VRRAAVHCMA NLCLSVPGQP YLEEPYQNVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK GIQSLLNGGR MKLTQTDELG ALLAVLKKFM FHGLPGLNIE MPTVLYPTPL PQYDGRTPIK PQQSESSASR PTLNKKKKSK VKPKKIQQGE EEEKESSGEI EAAPVTGTGR VNLHEGNTWC PSSLGVQSLP LDGSGAAEKD GVSSSFSSSS WKRVSSSESD FSDAEGGMQS KMRSYQAKVR QGALVCFLST IKSIEKKVLY GYWSAFIPDT PELGSPQSVS LMTLTLKDPS PKTRACALQV LSAILEGSKQ FLSVAEDTSD HRRAFTPFSV MIACSIRELH RCLLLALVAE SSSQTVTQII KCLANLVSNA PYDRLKLSLL TKVWNQIKPY IRHKDVNVRV SSLTLLGAIV STHAPLPEVQ LLLQQPCSSG LGNSNSATPH LSPPDWWKKA PAGPSLEETS VSSPKGSSEP CWLIRLCISI VVLPKEDSCS GSDAGSAAGS TYEPSPMRLE ALQVLTLLAR GYFSMTQAYL MELGEVICKC MGEADPSIQL HGAKLLEELG TGLIQQYKPD STAAPDQRAP VFLVVMFWTM MLNGPLPRAL QNSEHPTLQA SACDALSSIL PEAFSNLPND RQMLCITVLL GLNDSKNRLV KAATSRALGV YVLFPCLRQD VIFVADAANA ILMSLEDKSL NVRAKAAWSL GNLTDTLIVN METPDPSFQE EFSGLLLLKM LRSAIEASKD KDKVKSNAVR ALGNLLHFLQ PSHIEKPTFA EIIEESIQAL ISTVLTEAAM KVRWNACYAM GNVFKNPALP LGTAPWTSQA YNALTSVVTS CKNFKVRIRS AAALSVPGKR EQYGSVDQYA RIWNALVTAL QKSEDTIDFL EFKYCVSLRT QICQALIHLL SLASASDLPC MKETLELSGN MVQSYILQFL KSGAEGDDTG APHSPQERDQ MVRMALKHMG SIQAPTGDTA RRAIMGFLEE ILAVCFDSSG SQGALPGLTN Q
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