About BRD4-interacting chromatin-remodeling complex-associated protein-like
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) is a protein
from Homo sapiens identified by UniProt accession
Q6AI39, 1079 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | BRD4-interacting chromatin-remodeling complex-associated protein-like |
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| UniProt accession | Q6AI39 |
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| Gene | BICRAL |
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| Organism | Homo sapiens |
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| Length | 1079 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- alcohol drinking · score 0.23
- urate measurement · score 0.15
- autism spectrum disorder · score 0.12
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- chronic hepatitis · score 0.09
- hematocrit · score 0.07
- attention deficit hyperactivity disorder · score 0.04
- substance abuse · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6AI39-F1 | alphafold | PREDICTED | 45.71 | — |
Amino-acid sequence (1079 residues)
MDDDDDSCLL DLIGDPQALN YFLHGPSNKS SNDDLTNAGY SAANSNSIFA NSSNADPKSS LKGVSNQLGE GPSDGLPLSS SLQFLEDELE SSPLPDLTED QPFDILQKSL QEANITEQTL AEEAYLDASI GSSQQFAQAQ LHPSSSASFT QASNVSNYSG QTLQPIGVTH VPVGASFASN TVGVQHGFMQ HVGISVPSQH LSNSSQISGS GQIQLIGSFG NHPSMMTINN LDGSQIILKG SGQQAPSNVS GGLLVHRQTP NGNSLFGNSS SSPVAQPVTV PFNSTNFQTS LPVHNIIIQR GLAPNSNKVP INIQPKPIQM GQQNTYNVNN LGIQQHHVQQ GISFASASSP QGSVVGPHMS VNIVNQQNTR KPVTSQAVSS TGGSIVIHSP MGQPHAPQSQ FLIPTSLSVS SNSVHHVQTI NGQLLQTQPS QLISGQVASE HVMLNRNSSN MLRTNQPYTG PMLNNQNTAV HLVSGQTFAA SGSPVIANHA SPQLVGGQMP LQQASPTVLH LSPGQSSVSQ GRPGFATMPS VTSMSGPSRF PAVSSASTAH PSLGSAVQSG SSGSNFTGDQ LTQPNRTPVP VSVSHRLPVS SSKSTSTFSN TPGTGTQQQF FCQAQKKCLN QTSPISAPKT TDGLRQAQIP GLLSTTLPGQ DSGSKVISAS LGTAQPQQEK VVGSSPGHPA VQVESHSGGQ KRPAAKQLTK GAFILQQLQR DQAHTVTPDK SHFRSLSDAV QRLLSYHVCQ GSMPTEEDLR KVDNEFETVA TQLLKRTQAM LNKYRCLLLE DAMRINPSAE MVMIDRMFNQ EERASLSRDK RLALVDPEGF QADFCCSFKL DKAAHETQFG RSDQHGSKAS SSLQPPAKAQ GRDRAKTGVT EPMNHDQFHL VPNHIVVSAE GNISKKTECL GRALKFDKVG LVQYQSTSEE KASRREPLKA SQCSPGPEGH RKTSSRSDHG TESKLSSILA DSHLEMTCNN SFQDKSLRNS PKNEVLHTDI MKGSGEPQPD LQLTKSLETT FKNILELKKA GRQPQSDPTV SGSVELDFPN FSPMASQENC LEKFIPDHSE GVVETDSILE AAVNSILEC
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