About NADH-cytochrome b5 reductase 2
NADH-cytochrome b5 reductase 2 (CYB5R2) is a protein
from Homo sapiens identified by UniProt accession
Q6BCY4, 276 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | NADH-cytochrome b5 reductase 2 |
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| UniProt accession | Q6BCY4 |
|---|
| Gene | CYB5R2 |
|---|
| Organism | Homo sapiens |
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| Length | 276 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.06
- mean corpuscular volume · score 0.03
- Duane retraction syndrome · score 0.02
- mean reticulocyte volume · score 0.02
- lymph node metastatic carcinoma · score 0.01
- diffuse large B-cell lymphoma · score 0.01
- Abnormal sperm morphology · score 0.01
- diabetic retinopathy · score 0.01
- hepatocellular carcinoma · score 0.01
- myeloid sarcoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6BCY4-F1 | alphafold | PREDICTED | 95.80 | — |
Amino-acid sequence (276 residues)
MNSRRREPIT LQDPEAKYPL PLIEKEKISH NTRRFRFGLP SPDHVLGLPV GNYVQLLAKI DNELVVRAYT PVSSDDDRGF VDLIIKIYFK NVHPQYPEGG KMTQYLENMK IGETIFFRGP RGRLFYHGPG NLGIRPDQTS EPKKTLADHL GMIAGGTGIT PMLQLIRHIT KDPSDRTRMS LIFANQTEED ILVRKELEEI ARTHPDQFNL WYTLDRPPIG WKYSSGFVTA DMIKEHLPPP AKSTLILVCG PPPLIQTAAH PNLEKLGYTQ DMIFTY
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