About Multiple C2 and transmembrane domain-containing protein 2
Multiple C2 and transmembrane domain-containing protein 2 (MCTP2) is a protein
from Homo sapiens identified by UniProt accession
Q6DN12, 878 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Multiple C2 and transmembrane domain-containing protein 2 |
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| UniProt accession | Q6DN12 |
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| Gene | MCTP2 |
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| Organism | Homo sapiens |
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| Length | 878 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.39
- cortical surface area measurement · score 0.35
- PHF-tau measurement · score 0.33
- protein measurement · score 0.32
- brain measurement · score 0.28
- parental genotype effect measurement · score 0.27
- CCL24 measurement · score 0.27
- attention deficit hyperactivity disorder · score 0.24
- body mass index · score 0.21
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6DN12-F1 | alphafold | PREDICTED | 68.18 | — |
Amino-acid sequence (878 residues)
MDLDKPSVWG SLKQRTRPLL INLSKKKVKK NPSKPPDLRA RHHLDRRLSL SVPDLLEAEA LAPEGRPYSG PQSSYTSVPS SLSTAGIFPK SSSSSLKQSE EELDWSQEEA SHLHVVETDS EEAYASPAER RRVSSNGIFD LQKTSLGGDA PEEPEKLCGS SDLNASMTSQ HFEEQSVPGE ASDGLSNLPS PFAYLLTIHL KEGRNLVVRD RCGTSDPYVK FKLNGKTLYK SKVIYKNLNP VWDEIVVLPI QSLDQKLRVK VYDRDLTTSD FMGSAFVILS DLELNRTTEH ILKLEDPNSL EDDMGVIVLN LNLVVKQGDF KRHRWSNRKR LSASKSSLIR NLRLSESLKK NQLWNGIISI TLLEGKNVSG GSMTEMFVQL KLGDQRYKSK TLCKSANPQW QEQFDFHYFS DRMGILDIEV WGKDNKKHEE RLGTCKVDIS ALPLKQANCL ELPLDSCLGA LLMLVTLTPC AGVSVSDLCV CPLADLSERK QITQRYCLQN SLKDVKDVGI LQVKVLKAAD LLAADFSGKS DPFCLLELGN DRLQTHTVYK NLNPEWNKVF TFPIKDIHDV LEVTVFDEDG DKPPDFLGKV AIPLLSIRDG QPNCYVLKNK DLEQAFKGVI YLEMDLIYNP VKASIRTFTP REKRFVEDSR KLSKKILSRD VDRVKRITMA IWNTMQFLKS CFQWESTLRS TIAFAVFLIT VWNFELYMIP LALLLIFVYN FIRPVKGKVS SIQDSQESTD IDDEEDEDDK ESEKKGLIER IYMVQDIVST VQNVLEEIAS FGERIKNTFN WTVPFLSSLA CLILAAATII LYFIPLRYII LIWGINKFTK KLRNPYSIDN NELLDFLSRV PSDVQKVQYA ELKLCSSHSP LRKKRSAL
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