About XIAP-associated factor 1
XIAP-associated factor 1 (XAF1) is a protein
from Homo sapiens identified by UniProt accession
Q6GPH4, 301 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | XIAP-associated factor 1 |
|---|
| UniProt accession | Q6GPH4 |
|---|
| Gene | XAF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 301 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (155)
Diseases linked to this target (Open Targets).
- diffuse plaque measurement · score 0.19
- neoplasm · score 0.11
- cancer · score 0.09
- hepatocellular carcinoma · score 0.09
- melanoma · score 0.08
- glioblastoma multiforme · score 0.08
- neuroblastoma · score 0.08
- neutrophil count · score 0.06
- nonpapillary renal cell carcinoma · score 0.05
- viral disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6GPH4-F1 | alphafold | PREDICTED | 72.70 | — |
Amino-acid sequence (301 residues)
MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC KLEHQQVGCT MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL HESYCGSRTE LCQGCGQFIM HRMLAQHRDV CRSEQAQLGK GERISAPERE IYCHYCNQMI PENKYFHHMG KCCPDSEFKK HFPVGNPEIL PSSLPSQAAE NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD PLLMSEPKPR TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF S
Explore XIAP-associated factor 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets