About Chymotrypsinogen B2
Chymotrypsinogen B2 (CTRB2) is a protein
from Homo sapiens identified by UniProt accession
Q6GPI1, 263 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Chymotrypsinogen B2 |
|---|
| UniProt accession | Q6GPI1 |
|---|
| Gene | CTRB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 263 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.31
- diabetes mellitus · score 0.28
- neurodegenerative disease · score 0.27
- blood protein measurement · score 0.25
- breast adenocarcinoma · score 0.22
- type 1 diabetes mellitus · score 0.21
- age-related macular degeneration · score 0.20
- wet macular degeneration · score 0.19
- atrophic macular degeneration · score 0.19
- Drugs used in diabetes use measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6GPI1-F1 | alphafold | PREDICTED | 91.90 | — |
Amino-acid sequence (263 residues)
MAFLWLLSCW ALLGTTFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS LQDKTGFHFC GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV LKIAKVFKNP KFSILTVNND ITLLKLATPA RFSQTVSAVC LPSADDDFPA GTLCATTGWG KTKYNANKTP DKLQQAALPL LSNAECKKSW GRRITDVMIC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSRTCST TTPAVYARVA KLIPWVQKIL AAN
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