About Astacin-like metalloendopeptidase
Astacin-like metalloendopeptidase (ASTL) is a protein
from Homo sapiens identified by UniProt accession
Q6HA08, 431 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Astacin-like metalloendopeptidase |
|---|
| UniProt accession | Q6HA08 |
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| Gene | ASTL |
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| Organism | Homo sapiens |
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| Length | 431 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- oocyte maturation defect 11 · score 0.46
- diastolic blood pressure · score 0.32
- pulse pressure measurement · score 0.30
- neoplasm · score 0.09
- cancer · score 0.09
- Female infertility due to fertilization defect · score 0.08
- pancreatic neoplasm · score 0.07
- female infertility due to oocyte meiotic arrest · score 0.07
- monocyte percentage of leukocytes · score 0.07
- HbA1c measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6HA08-F1 | alphafold | PREDICTED | 69.99 | — |
Amino-acid sequence (431 residues)
MEGVGGLWPW VLGLLSLPGV ILGAPLASSC AGACGTSFPD GLTPEGTQAS GDKDIPAINQ GLILEETPES SFLIEGDIIR PSPFRLLSAT SNKWPMGGSG VVEVPFLLSS KYDEPSRQVI LEALAEFERS TCIRFVTYQD QRDFISIIPM YGCFSSVGRS GGMQVVSLAP TCLQKGRGIV LHELMHVLGF WHEHTRADRD RYIRVNWNEI LPGFEINFIK SQSSNMLTPY DYSSVMHYGR LAFSRRGLPT ITPLWAPSVH IGQRWNLSAS DITRVLKLYG CSPSGPRPRG RGSHAHSTGR SPAPASLSLQ RLLEALSAES RSPDPSGSSA GGQPVPAGPG ESPHGWESPA LKKLSAEASA RQPQTLASSP RSRPGAGAPG VAQEQSWLAG VSTKPTVPSS EAGIQPVPVQ GSPALPGGCV PRNHFKGMSE D
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