Single Ig IL-1-related receptor (SIGIRR)

About Single Ig IL-1-related receptor

Single Ig IL-1-related receptor (SIGIRR) is a protein from Homo sapiens identified by UniProt accession Q6IA17, 410 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	Single Ig IL-1-related receptor
UniProt accession	Q6IA17
Gene	SIGIRR
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (116)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.39
neurodegenerative disease · score 0.33
apolipoprotein A 1 measurement · score 0.32
creatinine measurement · score 0.25
C-reactive protein measurement · score 0.25
high density lipoprotein cholesterol measurement · score 0.23
triglyceride measurement · score 0.16
neutrophil percentage of leukocytes · score 0.16
nevus count · score 0.09
cutaneous melanoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6IA17-F1	alphafold	PREDICTED	75.16	—

Amino-acid sequence (410 residues)

MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL KDGLPLGIGG HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI QNISFSSFTL QRAGPTSHVA AVLASLLVLL ALLLAALLYV KCRLNVLLWY QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF VNFILKPQLE RRRGYKLFLD DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH SFREGLCRLL ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP DPEGDLGVRG PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards