About Glutamine-dependent NAD(+) synthetase
Glutamine-dependent NAD(+) synthetase (NADSYN1) is a protein
from Homo sapiens identified by UniProt accession
Q6IA69, 706 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Glutamine-dependent NAD(+) synthetase |
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| UniProt accession | Q6IA69 |
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| Gene | NADSYN1 |
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| Organism | Homo sapiens |
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| Length | 706 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (120)
Diseases linked to this target (Open Targets).
- Ulbright-Hodes syndrome · score 0.67
- congenital vertebral-cardiac-renal anomalies syndrome · score 0.63
- neurodegenerative disease · score 0.50
- vitamin D measurement · score 0.48
- Neurodevelopmental delay · score 0.34
- vitamin D deficiency · score 0.33
- vitamin D dietary intake measurement · score 0.26
- multiple sclerosis · score 0.24
- genetic disorder · score 0.19
- vertebral, cardiac, renal, and limb defects syndrome 1 · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IA69-F1 | alphafold | PREDICTED | 95.92 | — |
Amino-acid sequence (706 residues)
MGRKVTVATC ALNQWALDFE GNLQRILKSI EIAKNRGARY RLGPELEICG YGCWDHYYES DTLLHSFQVL AALVESPVTQ DIICDVGMPV MHRNVRYNCR VIFLNRKILL IRPKMALANE GNYRELRWFT PWSRSRHTEE YFLPRMIQDL TKQETVPFGD AVLVTWDTCI GSEICEELWT PHSPHIDMGL DGVEIITNAS GSHQVLRKAN TRVDLVTMVT SKNGGIYLLA NQKGCDGDRL YYDGCAMIAM NGSVFAQGSQ FSLDDVEVLT ATLDLEDVRS YRAEISSRNL AASRASPYPR VKVDFALSCH EDLLAPISEP IEWKYHSPEE EISLGPACWL WDFLRRSQQA GFLLPLSGGV DSAATACLIY SMCCQVCEAV RSGNEEVLAD VRTIVNQISY TPQDPRDLCG RILTTCYMAS KNSSQETCTR ARELAQQIGS HHISLNIDPA VKAVMGIFSL VTGKSPLFAA HGGSSRENLA LQNVQARIRM VLAYLFAQLS LWSRGVHGGL LVLGSANVDE SLLGYLTKYD CSSADINPIG GISKTDLRAF VQFCIQRFQL PALQSILLAP ATAELEPLAD GQVSQTDEED MGMTYAELSV YGKLRKVAKM GPYSMFCKLL GMWRHICTPR QVADKVKRFF SKYSMNRHKM TTLTPAYHAE NYSPEDNRFD LRPFLYNTSW PWQFRCIENQ VLQLERAEPQ SLDGVD
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