About Glycine N-acyltransferase
Glycine N-acyltransferase (GLYAT) is a protein
from Homo sapiens identified by UniProt accession
Q6IB77, 296 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | Glycine N-acyltransferase |
|---|
| UniProt accession | Q6IB77 |
|---|
| Gene | GLYAT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 296 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (119)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- cutaneous melanoma · score 0.26
- lung adenocarcinoma · score 0.26
- hypertrophic cardiomyopathy · score 0.23
- monocyte count · score 0.16
- glioblastoma multiforme · score 0.16
- head and neck squamous cell carcinoma · score 0.15
- inflammatory bowel disease · score 0.15
- ulcerative colitis · score 0.12
- body height · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IB77-F1 | alphafold | PREDICTED | 95.64 | — |
Amino-acid sequence (296 residues)
MMLPLQGAQM LQMLEKSLRK SLPASLKVYG TVFHINHGNP FNLKAVVDKW PDFNTVVVCP QEQDMTDDLD HYTNTYQIYS KDPQNCQEFL GSPELINWKQ HLQIQSSQPS LNEAIQNLAA IKSFKVKQTQ RILYMAAETA KELTPFLLKS KILSPNGGKP KAINQEMFKL SSMDVTHAHL VNKFWHFGGN ERSQRFIERC IQTFPTCCLL GPEGTPVCWD LMDQTGEMRM AGTLPEYRLH GLVTYVIYSH AQKLGKLGFP VYSHVDYSNE AMQKMSYTLQ HVPIPRSWNQ WNCVPL
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