About Condensin-2 complex subunit H2
Condensin-2 complex subunit H2 (NCAPH2) is a protein
from Homo sapiens identified by UniProt accession
Q6IBW4, 605 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Condensin-2 complex subunit H2 |
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| UniProt accession | Q6IBW4 |
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| Gene | NCAPH2 |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- fatal infantile encephalocardiomyopathy · score 0.56
- cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1 · score 0.56
- myopia 6 · score 0.51
- Seizure · score 0.34
- Severe global developmental delay · score 0.34
- Tip-toe gait · score 0.34
- dilated cardiomyopathy · score 0.27
- genetic disorder · score 0.19
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.19
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IBW4-F1 | alphafold | PREDICTED | 62.42 | — |
Amino-acid sequence (605 residues)
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP SMAQP
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