Desumoylating isopeptidase 1 (DESI1)

About Desumoylating isopeptidase 1

Desumoylating isopeptidase 1 (DESI1) is a protein from Homo sapiens identified by UniProt accession Q6ICB0, 168 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Desumoylating isopeptidase 1
UniProt accession	Q6ICB0
Gene	DESI1
Organism	Homo sapiens
Length	168 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.14
smoking status measurement · score 0.07
asthma · score 0.06
diet measurement · score 0.06
mathematical ability · score 0.06
alcohol consumption measurement · score 0.05
body fat percentage · score 0.05
fat body mass · score 0.04
respiratory system disease · score 0.04
platelet crit · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ICB0-F1	alphafold	PREDICTED	93.47	—

Amino-acid sequence (168 residues)

MEPPNLYPVK LYVYDLSKGL ARRLSPIMLG KQLEGIWHTS IVVHKDEFFF GSGGISSCPP GGTLLGPPDS VVDVGSTEVT EEIFLEYLSS LGESLFRGEA YNLFEHNCNT FSNEVAQFLT GRKIPSYITD LPSEVLSTPF GQALRPLLDS IQIQPPGGSS VGRPNGQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards