About Transport and Golgi organization protein 2 homolog
Transport and Golgi organization protein 2 homolog (TANGO2) is a protein
from Homo sapiens identified by UniProt accession
Q6ICL3, 276 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Transport and Golgi organization protein 2 homolog |
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| UniProt accession | Q6ICL3 |
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| Gene | TANGO2 |
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| Organism | Homo sapiens |
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| Length | 276 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (92)
Diseases linked to this target (Open Targets).
- recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome · score 0.80
- Intellectual disability · score 0.49
- Acute rhabdomyolysis · score 0.48
- Seizure · score 0.48
- cardiac arrhythmia · score 0.48
- Episodic flaccid weakness · score 0.48
- genetic disorder · score 0.47
- Abnormality of metabolism/homeostasis · score 0.34
- Global developmental delay · score 0.33
- Delayed speech and language development · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6ICL3-F1 | alphafold | PREDICTED | 95.37 | — |
Amino-acid sequence (276 residues)
MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL DMEEGKEGGT WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV DSLSYLKKVS MEGHLYNGFN LIAADLSTAK GDVICYYGNR GEPDPIVLTP GTYGLSNALL ETPWRKLCFG KQLFLEAVER SQALPKDVLI ASLLDVLNNE EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT IILVDADGHV TFTERSMMDK DLSHWETRTY EFTLQS
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