rRNA methyltransferase 1, mitochondrial (MRM1)

About rRNA methyltransferase 1, mitochondrial

rRNA methyltransferase 1, mitochondrial (MRM1) is a protein from Homo sapiens identified by UniProt accession Q6IN84, 353 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	rRNA methyltransferase 1, mitochondrial
UniProt accession	Q6IN84
Gene	MRM1
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

macrophage inflammatory protein 1b measurement · score 0.27
blood protein measurement · score 0.27
neurodegenerative disease · score 0.26
body mass index · score 0.23
mathematical ability · score 0.21
cystatin C measurement · score 0.17
creatinine measurement · score 0.11
high density lipoprotein cholesterol measurement · score 0.06
physical activity · score 0.06
self reported educational attainment · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6IN84-F1	alphafold	PREDICTED	78.72	—

Amino-acid sequence (353 residues)

MALLSTVRGA TWGRLVTRHF SHAARHGERP GGEELSRLLL DDLVPTSRLE LLFGMTPCLL ALQAARRSVA RLLLQAGKAG LQGKRAELLR MAEARDIPVL RPRRQKLDTM CRYQVHQGVC MEVSPLRPRP WREAGEASPG DDPQQLWLVL DGIQDPRNFG AVLRSAHFLG VDKVITSRRN SCPLTPVVSK SSAGAMEVMD VFSTDDLTGF LQTKAQQGWL VAGTVGCPST EDPQSSEIPI MSCLEFLWER PTLLVLGNEG SGLSQEVQAS CQLLLTILPR RQLPPGLESL NVSVAAGILL HSICSQRKGF PTEGERRQLL QDPQEPSARS EGLSMAQHPG LSSGPEKERQ NEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards