About Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A (PPP4R3A) is a protein
from Homo sapiens identified by UniProt accession
Q6IN85, 833 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 4 regulatory subunit 3A |
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| UniProt accession | Q6IN85 |
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| Gene | PPP4R3A |
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| Organism | Homo sapiens |
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| Length | 833 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.43
- mean reticulocyte volume · score 0.37
- mean corpuscular hemoglobin concentration · score 0.34
- mean corpuscular hemoglobin · score 0.32
- white matter microstructure measurement · score 0.31
- type 2 diabetes mellitus · score 0.30
- brain volume measurement · score 0.30
- sex hormone-binding globulin measurement · score 0.29
- Drugs used in diabetes use measurement · score 0.25
- red blood cell density measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IN85-F1 | alphafold | PREDICTED | 77.21 | — |
Amino-acid sequence (833 residues)
MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL LLESKINPNT AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVDIT QDLVDESEEE RFDDMSSPGL ELPSCELSRL EEIAELVASS LPSPLRREKL ALALENEGYI KKLLELFHVC EDLENIEGLH HLYEIIKGIF LLNRTALFEV MFSEECIMDV IGCLEYDPAL SQPRKHREFL TKTAKFKEVI PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR DAFFKTLSNM GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV MQEAQQNDDV SKKLTEQKIT SKDILLINLI IEHMICDTDP ELGGAVQLMG LLRTLVDPEN MLATANKTEK TEFLGFFYKH CMHVLTAPLL ANTTEDKPSK DDFQTAQLLA LVLELLTFCV EHHTYHIKNY IINKDILRRV LVLMASKHAF LALCALRFKR KIIGLKDEFY NRYIMKSFLF EPVVKAFLNN GSRYNLMNSA IIEMFEFIRV EDIKSLTAHV IENYWKALED VDYVQTFKGL KLRFEQQRER QDNPKLDSMR SILRNHRYRR DARTLEDEEE MWFNTDEDDM EDGEAVVSPS DKTKNDDDIM DPISKFMERK KLKESEEKEV LLKTNLSGRQ SPSFKLSLSS GTKTNLTSQS STTNLPGSPG SPGSPGSPGS PGSVPKNTSQ TAAITTKGGL VGLVDYPDDD EDDDEDEDKE DTLPLSKKAK FDS
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