Centromere protein P (CENPP)

About Centromere protein P

Centromere protein P (CENPP) is a protein from Homo sapiens identified by UniProt accession Q6IPU0, 288 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Centromere protein P
UniProt accession	Q6IPU0
Gene	CENPP
Organism	Homo sapiens
Length	288 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

autosomal dominant nonsyndromic hearing loss · score 0.37
neurodegenerative disease · score 0.34
Low-frequency sensorineural hearing impairment · score 0.27
urate measurement · score 0.25
BMI-adjusted waist-hip ratio · score 0.22
osteoarthritis · score 0.18
triglyceride measurement · score 0.18
high density lipoprotein cholesterol measurement · score 0.18
hemorrhoid · score 0.17
creatinine measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6IPU0-F1	alphafold	PREDICTED	84.98	—

Amino-acid sequence (288 residues)

MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards