About Centriole, cilia and spindle-associated protein
Centriole, cilia and spindle-associated protein (CCSAP) is a protein
from Homo sapiens identified by UniProt accession
Q6IQ19, 270 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Centriole, cilia and spindle-associated protein |
|---|
| UniProt accession | Q6IQ19 |
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| Gene | CCSAP |
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| Organism | Homo sapiens |
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| Length | 270 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- peak expiratory flow · score 0.12
- FEV/FVC ratio · score 0.11
- refractive error measurement · score 0.09
- PHF-tau measurement · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- attention deficit-hyperactivity disorder 8 · score 0.05
- schizophrenia 15 · score 0.05
- Tourette syndrome · score 0.05
- autism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IQ19-F1 | alphafold | PREDICTED | 63.04 | — |
Amino-acid sequence (270 residues)
MSPGSGVKSE YMKRYQEPRW EEYGPCYREL LHYRLGRRLL EQAHAPWLWD DWGPAGSSED SASSESSGAG GPAPRCAPPS PPPPVEPATQ EEAERRARGA PEEQDAEAGD AEAEDAEDAA LPALPVKDVE DKPEQQTRTR ETDKSPTSTE PRQQPSALFA RGNRKAVKSP QRSSSKIKEN KHPFALYGWG EKQTDTGSQK THNVCASAPV HEIHESALRA KNRRQVEKRK LVAQRQRAHS VDVEKNRKMK ASSSENPWMT EYMRCYSARA
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