About Activity-dependent neuroprotector homeobox protein 2
Activity-dependent neuroprotector homeobox protein 2 (ADNP2) is a protein
from Homo sapiens identified by UniProt accession
Q6IQ32, 1131 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Activity-dependent neuroprotector homeobox protein 2 |
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| UniProt accession | Q6IQ32 |
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| Gene | ADNP2 |
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| Organism | Homo sapiens |
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| Length | 1131 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- Abnormal abdomen morphology · score 0.21
- Abnormal delivery · score 0.21
- age-related hearing impairment · score 0.19
- acne · score 0.10
- leukocyte count · score 0.06
- neutrophil count · score 0.05
- Eiken syndrome · score 0.03
- appendicular lean mass · score 0.03
- Burkitts lymphoma · score 0.03
- metaphyseal dysplasia, Braun-Tinschert type · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IQ32-F1 | alphafold | PREDICTED | 56.89 | — |
Amino-acid sequence (1131 residues)
MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN TSWGDVSLWE PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI DQELVIPCPN CVFASQPKVV GRHFRMFHAP VRKVQNYTVN ILGETKSSRS DVISFTCLKC NFSNTLYYSM KKHVLVAHFH YLINSYFGLR TEEMGEQPKT NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH RDLENKLRSV ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP APQPVFLSHG VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV LPLTQPVGPI NRPVGPGVLP VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ MVQSGVLPVG QTAPSRVLPP GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS GVLQLSQPVV SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA PMAGSMPGMP SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN ELFPSNVYQV HMEVAHKHSE SKSGEKLEPE KLAACAPFLK WMREKTVRCL SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH DIKGLSEHSR NRHLGKKKLP MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY LAILAGIHSK SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ AQPGFIHNSE LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL NADAAPGPEK VTSVVPFKRQ RNESRTEGPI VKDEALQILA LDPKKYEGRS YEEKKQFLKD YFHKKPYPSK KEIELLSSLF WVWKIDVASF FGKRRYICMK AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P
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