About Splicing regulator SDE2
Splicing regulator SDE2 (SDE2) is a protein
from Homo sapiens identified by UniProt accession
Q6IQ49, 451 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Splicing regulator SDE2 |
|---|
| UniProt accession | Q6IQ49 |
|---|
| Gene | SDE2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 451 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- toxoplasmosis · score 0.09
- protein measurement · score 0.08
- juvenile dermatomyositis · score 0.01
- Sepsis · score 0.01
- chronic kidney disease · score 0.01
- cancer · score 0.01
- urinary bladder carcinoma · score 0.01
- neoplasm · score 0.00
- IGA glomerulonephritis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IQ49-F1 | alphafold | PREDICTED | 65.18 | — |
Amino-acid sequence (451 residues)
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK CNGALINTSD TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA CRDLSGRRLR DVNHEKAMAE WVKQQAEREA EKEQKRLERL QRKLVEPKHC FTSPDYQQQC HEMAERLEDS VLKGMQAASS KMVSAEISEN RKRQWPTKSQ TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS TSGMGFHAPK IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD GERVAEVAPE ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG LEKLKCELMA LGLKCGGTLQ ERAARLFSVR GLAKEQIDPA LFAKPLKGKK K
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