About Zinc finger protein 425
Zinc finger protein 425 (ZNF425) is a protein
from Homo sapiens identified by UniProt accession
Q6IV72, 752 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Zinc finger protein 425 |
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| UniProt accession | Q6IV72 |
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| Gene | ZNF425 |
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| Organism | Homo sapiens |
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| Length | 752 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.35
- neutrophil percentage of leukocytes · score 0.32
- sum of basophil and neutrophil counts · score 0.26
- neurodegenerative disease · score 0.24
- basophil percentage of leukocytes · score 0.23
- sum of neutrophil and eosinophil counts · score 0.23
- myeloid white cell count · score 0.23
- leukocyte count · score 0.21
- brain volume measurement · score 0.15
- neuroimaging measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IV72-F1 | alphafold | PREDICTED | 72.19 | — |
Amino-acid sequence (752 residues)
MAEPASVTVT FDDVALYFSE QEWEILEKWQ KQMYKQEMKT NYETLDSLGY AFSKPDLITW MEQGRMLLIS EQGCLDKTRR TTSPPTDEQL NMKNTGKLLC FDDEGTPRTK EEDCRLNGPQ KQDLCAALRG KERKILLAQT ATFQSPSLRE TEILNKKVSI TAYDPDKKDL RHKPRETPGR LEIPTGPRCY SCYVCRKVFQ VRRDLLKHKR SHSKSQLCRY PKYKNSSRGK SELRRTQRLL CQKKRFQCSE CEKSYFLKGS LVTHQVVHTG QRPYPCPECD KTFRYRANLK KHLCLHRGER PFCCGECGRA FVQQCELTEH LRLHSGEKPF QCPQCDRCFR LKRGMKVHLT QHSGKRPFHC PECGRSFSRK AALKTHQRTH SEEKPFSCGE CGRKFIYKIK LDEHIRVHTG EKPFSCPECN KSFRLKRSLK AHGLQHIGKR PFQCPECSRG FFWRNAMRAH QRLHSEQKPF PCAECGKRFT RPSKLACHTR VHDRQKEFPC GECKKTFSQQ SRLTQHLKVH TTEKPFSCAE CGRSFRRRAH LTEHTRLHSG EEPFQCPECD KSFSWKASMK FHQRMHRDEK PFACGECDKT YTHQSQLTEH LRLHSGEKPY QCPECEKTFR LKGNLKSHLL QHSGQKPFSC VMCGKSFTQQ YRLTEHIRVH SGEKPFQCPE CDKSYCIRGS LKVHLYKHSG ERPFQCPECG KGFLQKRSLK AHLCLHSGER PFSCDECGRS FTYVGALKTH IAVHAKEKPS SL
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