About Kelch-like protein 10
Kelch-like protein 10 (KLHL10) is a protein
from Homo sapiens identified by UniProt accession
Q6JEL2, 608 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Kelch-like protein 10 |
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| UniProt accession | Q6JEL2 |
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| Gene | KLHL10 |
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| Organism | Homo sapiens |
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| Length | 608 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- spermatogenic failure 11 · score 0.59
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
- azoospermia · score 0.17
- Immature Reticulocyte Fraction Measurement · score 0.12
- reticulocyte measurement · score 0.10
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure, X-linked, 2 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6JEL2-F1 | alphafold | PREDICTED | 91.75 | — |
Amino-acid sequence (608 residues)
MEMESAAAST RFHQPHMERK MSAMACEIFN ELRLEGKLCD VVIKVNGFEF SAHKNILCSC SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN IMGIVRGCCE FLKSELCLDN CIGICKFTDY YYCPELRQKA YMFILHNFEE MVKVSAEFLE LSVTELKDII EKDELNVKQE DAVFEAILKW ISHDPQNRKQ HISILLPKVR LALMHAEYFM NNVKMNDYVK DSEECKPVII NALKAMYDLN MNGPSNSDFT NPLTRPRLPY AILFAIGGWS GGSPTNAIEA YDARADRWVN VTCEEESPRA YHGAAYLKGY VYIIGGFDSV DYFNSVKRFD PVKKTWHQVA PMHSRRCYVS VTVLGNFIYA MGGFDGYVRL NTAERYEPET NQWTLIAPMH EQRSDASATT LYGKVYICGG FNGNECLFTA EVYNTESNQW TVIAPMRSRR SGIGVIAYGE HVYAVGGFDG ANRLRSAEAY SPVANTWRTI PTMFNPRSNF GIEVVDDLLF VVGGFNGFTT TFNVECYDEK TDEWYDAHDM SIYRSALSCC VVPGLANVEE YAARRDNFPG LALRDEVKYS ASTSTLPV
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