About Pyrin and HIN domain-containing protein 1
Pyrin and HIN domain-containing protein 1 (PYHIN1) is a protein
from Homo sapiens identified by UniProt accession
Q6K0P9, 492 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Pyrin and HIN domain-containing protein 1 |
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| UniProt accession | Q6K0P9 |
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| Gene | PYHIN1 |
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| Organism | Homo sapiens |
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| Length | 492 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- asthma · score 0.28
- mean corpuscular volume · score 0.23
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- neoplasm · score 0.05
- retinitis pigmentosa and erythrocytic microcytosis · score 0.04
- oral squamous cell carcinoma · score 0.04
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6K0P9-F1 | alphafold | PREDICTED | 71.66 | — |
Amino-acid sequence (492 residues)
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS SDTSTNRHPA VP
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