About Keratin, type II cytoskeletal 80
Keratin, type II cytoskeletal 80 (KRT80) is a protein
from Homo sapiens identified by UniProt accession
Q6KB66, 452 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 80 |
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| UniProt accession | Q6KB66 |
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| Gene | KRT80 |
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| Organism | Homo sapiens |
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| Length | 452 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (108)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.19
- clear cell renal carcinoma · score 0.18
- drug use measurement · score 0.12
- lung adenocarcinoma · score 0.09
- colorectal carcinoma · score 0.09
- non-small cell lung carcinoma · score 0.08
- breast cancer · score 0.08
- cancer · score 0.07
- Fuchs endothelial corneal dystrophy · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6KB66-F1 | alphafold | PREDICTED | 75.48 | — |
Amino-acid sequence (452 residues)
MACRSCVVGF SSLSSCEVTP VGSPRPGTSG WDSCRAPGPG FSSRSLTGCW SAGTISKVTV NPGLLVPLDV KLDPAVQQLK NQEKEEMKAL NDKFASLIGK VQALEQRNQL LETRWSFLQG QDSAIFDLGH LYEEYQGRLQ EELRKVSQER GQLEANLLQV LEKVEEFRIR YEDEISKRTD MEFTFVQLKK DLDAECLHRT ELETKLKSLE SFVELMKTIY EQELKDLAAQ VKDVSVTVGM DSRCHIDLSG IVEEVKAQYD AVAARSLEEA EAYSRSQLEE QAARSAEYGS SLQSSRSEIA DLNVRIQKLR SQILSVKSHC LKLEENIKTA EEQGELAFQD AKTKLAQLEA ALQQAKQDMA RQLRKYQELM NVKLALDIEI ATYRKLVEGE EGRMDSPSAT VVSAVQSRCK TAASRSGLSK APSRKKKGSK GPVIKITEMS EKYFSQESEV SE
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