About Follistatin-related protein 4
Follistatin-related protein 4 (FSTL4) is a protein
from Homo sapiens identified by UniProt accession
Q6MZW2, 842 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Follistatin-related protein 4 |
|---|
| UniProt accession | Q6MZW2 |
|---|
| Gene | FSTL4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 842 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- diffuse plaque measurement · score 0.33
- gut microbiome measurement · score 0.27
- rheumatoid arthritis · score 0.25
- PHF-tau measurement · score 0.22
- drug use measurement · score 0.11
- central nervous system cancer · score 0.04
- eosinophil count · score 0.03
- hepatocellular carcinoma · score 0.02
- Sepsis · score 0.02
- glioblastoma multiforme · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6MZW2-F1 | alphafold | PREDICTED | 80.93 | — |
Amino-acid sequence (842 residues)
MKPGGFWLHL TLLGASLPAA LGWMDPGTSR GPDVGVGESQ AEEPRSFEVT RREGLSSHNE LLASCGKKFC SRGSRCVLSR KTGEPECQCL EACRPSYVPV CGSDGRFYEN HCKLHRAACL LGKRITVIHS KDCFLKGDTC TMAGYARLKN VLLALQTRLQ PLQEGDSRQD PASQKRLLVE SLFRDLDADG NGHLSSSELA QHVLKKQDLD EDLLGCSPGD LLRFDDYNSD SSLTLREFYM AFQVVQLSLA PEDRVSVTTV TVGLSTVLTC AVHGDLRPPI IWKRNGLTLN FLDLEDINDF GEDDSLYITK VTTIHMGNYT CHASGHEQLF QTHVLQVNVP PVIRVYPESQ AQEPGVAASL RCHAEGIPMP RITWLKNGVD VSTQMSKQLS LLANGSELHI SSVRYEDTGA YTCIAKNEVG VDEDISSLFI EDSARKTLAN ILWREEGLSV GNMFYVFSDD GIIVIHPVDC EIQRHLKPTE KIFMSYEEIC PQREKNATQP CQWVSAVNVR NRYIYVAQPA LSRVLVVDIQ AQKVLQSIGV DPLPAKLSYD KSHDQVWVLS WGDVHKSRPS LQVITEASTG QSQHLIRTPF AGVDDFFIPP TNLIINHIRF GFIFNKSDPA VHKVDLETMM PLKTIGLHHH GCVPQAMAHT HLGGYFFIQC RQDSPASAAR QLLVDSVTDS VLGPNGDVTG TPHTSPDGRF IVSAAADSPW LHVQEITVRG EIQTLYDLQI NSGISDLAFQ RSFTESNQYN IYAALHTEPD LLFLELSTGK VGMLKNLKEP PAGPAQPWGG THRIMRDSGL FGQYLLTPAR ESLFLINGRQ NTLRCEVSGI KGGTTVVWVG EV
Explore Follistatin-related protein 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets