MFS-type transporter SLC18B1 (SLC18B1)

About MFS-type transporter SLC18B1

MFS-type transporter SLC18B1 (SLC18B1) is a protein from Homo sapiens identified by UniProt accession Q6NT16, 456 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	MFS-type transporter SLC18B1
UniProt accession	Q6NT16
Gene	SLC18B1
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.33
cortical surface area measurement · score 0.27
Parkinson disease · score 0.24
electrocardiography · score 0.22
DNA methylation · score 0.16
bone density · score 0.13
bone quantitative ultrasound measurement · score 0.07
vitamin B12 deficiency · score 0.06
metabolite measurement · score 0.02
ovarian carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6NT16-F1	alphafold	PREDICTED	84.61	—

Amino-acid sequence (456 residues)

MEALGDLEGP RAPGGDDPAG SAGETPGWLS REQVFVLISA ASVNLGSMMC YSILGPFFPK EAEKKGASNT IIGMIFGCFA LFELLASLVF GNYLVHIGAK FMFVAGMFVS GGVTILFGVL DRVPDGPVFI AMCFLVRVMD AVSFAAAMTA SSSILAKAFP NNVATVLGSL ETFSGLGLIL GPPVGGFLYQ SFGYEVPFIV LGCVVLLMVP LNMYILPNYE SDPGEHSFWK LIALPKVGLI AFVINSLSSC FGFLDPTLSL FVLEKFNLPA GYVGLVFLGM ALSYAISSPL FGLLSDKRPP LRKWLLVFGN LITAGCYMLL GPVPILHIKS QLWLLVLILV VSGLSAGMSI IPTFPEILSC AHENGFEEGL STLGLVSGLF SAMWSIGAFM GPTLGGFLYE KIGFEWAAAI QGLWALISGL AMGLFYLLEY SRRKRSKSQN ILSTEEERTT LLPNET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards