About Carboxylesterase 5A
Carboxylesterase 5A (CES5A) is a protein
from Homo sapiens identified by UniProt accession
Q6NT32, 575 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Carboxylesterase 5A |
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| UniProt accession | Q6NT32 |
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| Gene | CES5A |
|---|
| Organism | Homo sapiens |
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| Length | 575 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (93)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.36
- gut microbiome measurement · score 0.32
- chronotype measurement · score 0.29
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 63 · score 0.06
- spermatogenic failure 7 · score 0.06
- spermatogenic failure 56 · score 0.06
- spermatogenic failure 65 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NT32-F1 | alphafold | PREDICTED | 90.48 | — |
Amino-acid sequence (575 residues)
MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV HYPKFGVSED CLYLNIYAPA HADTGSKLPV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL PMKEAPEILS GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV KADHADEVRF VFGGAFLKGD IVMFEGATEE EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP
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