About Ultra-long-chain fatty acid omega-hydroxylase
Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22) is a protein
from Homo sapiens identified by UniProt accession
Q6NT55, 531 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Ultra-long-chain fatty acid omega-hydroxylase |
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| UniProt accession | Q6NT55 |
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| Gene | CYP4F22 |
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| Organism | Homo sapiens |
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| Length | 531 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- lamellar ichthyosis · score 0.66
- autosomal recessive congenital ichthyosis · score 0.38
- cutaneous melanoma · score 0.26
- glioblastoma multiforme · score 0.23
- genetic disorder · score 0.19
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- ichthyosis · score 0.15
- congenital reticular ichthyosiform erythroderma · score 0.15
- atopic eczema · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NT55-F1 | alphafold | PREDICTED | 93.51 | — |
Amino-acid sequence (531 residues)
MLPITDRLLH LLGLEKTAFR IYAVSTLLLF LLFFLFRLLL RFLRLCRSFY ITCRRLRCFP QPPRRNWLLG HLGMYLPNEA GLQDEKKVLD NMHHVLLVWM GPVLPLLVLV HPDYIKPLLG ASAAIAPKDD LFYGFLKPWL GDGLLLSKGD KWSRHRRLLT PAFHFDILKP YMKIFNQSAD IMHAKWRHLA EGSAVSLDMF EHISLMTLDS LQKCVFSYNS NCQEKMSDYI SAIIELSALS VRRQYRLHHY LDFIYYRSAD GRRFRQACDM VHHFTTEVIQ ERRRALRQQG AEAWLKAKQG KTLDFIDVLL LARDEDGKEL SDEDIRAEAD TFMFEGHDTT SSGISWMLFN LAKYPEYQEK CREEIQEVMK GRELEELEWD DLTQLPFTTM CIKESLRQYP PVTLVSRQCT EDIKLPDGRI IPKGIICLVS IYGTHHNPTV WPDSKVYNPY RFDPDNPQQR SPLAYVPFSA GPRNCIGQSF AMAELRVVVA LTLLRFRLSV DRTRKVRRKP ELILRTENGL WLKVEPLPPR A
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