Homeobox-containing protein 1 (HMBOX1)

About Homeobox-containing protein 1

Homeobox-containing protein 1 (HMBOX1) is a protein from Homo sapiens identified by UniProt accession Q6NT76, 420 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Homeobox-containing protein 1
UniProt accession	Q6NT76
Gene	HMBOX1
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

generalized anxiety disorder · score 0.10
cancer · score 0.08
osteosarcoma · score 0.07
neoplasm · score 0.05
Sepsis · score 0.04
low density lipoprotein cholesterol measurement · score 0.04
self reported educational attainment · score 0.04
hemoglobin D disease · score 0.04
hemolytic anemia due to glutathione reductase deficiency · score 0.04
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6NT76-F1	alphafold	PREDICTED	68.28	—

Amino-acid sequence (420 residues)

MLSSFPVVLL ETMSHYTDEP RFTIEQIDLL QRLRRTGMTK HEILHALETL DRLDQEHSDK FGRRSSYGGS SYGNSTNNVP ASSSTATAST QTQHSGMSPS PSNSYDTSPQ PCTTNQNGRE NNERLSTSNG KMSPTRYHAN SMGQRSYSFE ASEEDLDVDD KVEELMRRDS SVIKEEIKAF LANRRISQAV VAQVTGISQS RISHWLLQQG SDLSEQKKRA FYRWYQLEKT NPGATLSMRP APIPIEDPEW RQTPPPVSAT SGTFRLRRGS RFTWRKECLA VMESYFNENQ YPDEAKREEI ANACNAVIQK PGKKLSDLER VTSLKVYNWF ANRRKEIKRR ANIEAAILES HGIDVQSPGG HSNSDDVDGN DYSEQDDSTS HSDHQDPISL AVEMAAVNHT ILALARQGAN EIKTEALDDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards