TMF-regulated nuclear protein 1 (TRNP1)

About TMF-regulated nuclear protein 1

TMF-regulated nuclear protein 1 (TRNP1) is a protein from Homo sapiens identified by UniProt accession Q6NT89, 227 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	TMF-regulated nuclear protein 1
UniProt accession	Q6NT89
Gene	TRNP1
Organism	Homo sapiens
Length	227 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

apolipoprotein A 1 measurement · score 0.19
high density lipoprotein cholesterol measurement · score 0.19
neutrophil count · score 0.13
leukocyte count · score 0.11
heel bone mineral density · score 0.07
hepatocellular carcinoma · score 0.06
esophageal squamous cell carcinoma · score 0.04
low density lipoprotein cholesterol measurement · score 0.03
Colon Sessile Serrated Adenoma/Polyp · score 0.03
myeloid white cell count · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6NT89-F1	alphafold	PREDICTED	68.94	—

Amino-acid sequence (227 residues)

MPGCRISACG PGAQEGTAEQ RSPPPPWDPM PSSQPPPPTP TLTPTPTPGQ SPPLPDAAGA SAGAAEDQEL QRWRQGASGI AGLAGPGGGS GAAAGAGGRA LELAEARRRL LEVEGRRRLV SELESRVLQL HRVFLAAELR LAHRAESLSR LSGGVAQAEL YLAAHGSRLK KGPRRGRRGR PPALLASALG LGGCVPWGAG RLRRGHGPEP DSPFRRSPPR GPASPQR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards