About Glycerol-3-phosphate acyltransferase 2, mitochondrial
Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2) is a protein
from Homo sapiens identified by UniProt accession
Q6NUI2, 795 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | Glycerol-3-phosphate acyltransferase 2, mitochondrial |
|---|
| UniProt accession | Q6NUI2 |
|---|
| Gene | GPAT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 795 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (119)
Diseases linked to this target (Open Targets).
- male infertility · score 0.38
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.07
- diastolic blood pressure · score 0.07
- spinocerebellar ataxia type 32 · score 0.06
- spermatogenic failures 50 · score 0.06
- cystatin C measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUI2-F1 | alphafold | PREDICTED | 78.08 | — |
Amino-acid sequence (795 residues)
MATMLEGRCQ TQPRSSPSGR EASLWSSGFG MKLEAVTPFL GKYRPFVGRC CQTCTPKSWE SLFHRSITDL GFCNVILVKE ENTRFRGWLV RRLCYFLWSL EQHIPPCQDV PQKIMESTGV QNLLSGRVPG GTGEGQVPDL VKKEVQRILG HIQAPPRPFL VRLFSWALLR FLNCLFLNVQ LHKGQMKMVQ KAAQAGLPLV LLSTHKTLLD GILLPFMLLS QGLGVLRVAW DSRACSPALR ALLRKLGGLF LPPEASLSLD SSEGLLARAV VQAVIEQLLV SGQPLLIFLE EPPGALGPRL SALGQAWVGF VVQAVQVGIV PDALLVPVAV TYDLVPDAPC DIDHASAPLG LWTGALAVLR SLWSRWGCSH RICSRVHLAQ PFSLQEYIVS ARSCWGGRQT LEQLLQPIVL GQCTAVPDTE KEQEWTPITG PLLALKEEDQ LLVRRLSCHV LSASVGSSAV MSTAIMATLL LFKHQKLLGE FSWLTEEILL RGFDVGFSGQ LRSLLQHSLS LLRAHVALLR IRQGDLLVVP QPGPGLTHLA QLSAELLPVF LSEAVGACAV RGLLAGRVPP QGPWELQGIL LLSQNELYRQ ILLLMHLLPQ DLLLLKPCQS SYCYCQEVLD RLIQCGLLVA EETPGSRPAC DTGRQRLSRK LLWKPSGDFT DSDSDDFGEA DGRYFRLSQQ SHCPDFFLFL CRLLSPLLKA FAQAAAFLRQ GQLPDTELGY TEQLFQFLQA TAQEEGIFEC ADPKLAISAV WTFRDLGVLQ QTPSPAGPRL HLSPTFASLD NQEKLEQFIR QFICS
Explore Glycerol-3-phosphate acyltransferase 2, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets