About Mitochondrial adenyl nucleotide antiporter SLC25A24
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) is a protein
from Homo sapiens identified by UniProt accession
Q6NUK1, 477 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Mitochondrial adenyl nucleotide antiporter SLC25A24 |
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| UniProt accession | Q6NUK1 |
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| Gene | SLC25A24 |
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| Organism | Homo sapiens |
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| Length | 477 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (72)
Diseases linked to this target (Open Targets).
- Fontaine progeroid syndrome · score 0.73
- Progeroid syndrome, Petty type · score 0.55
- neutrophil count · score 0.45
- leukocyte count · score 0.43
- myeloid white cell count · score 0.40
- monocyte percentage of leukocytes · score 0.39
- neutrophil percentage of leukocytes · score 0.36
- Bilateral tonic-clonic seizure · score 0.30
- dementia · score 0.30
- granulocyte percentage of myeloid white cells · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUK1-F1 | alphafold | PREDICTED | 81.34 | — |
Amino-acid sequence (477 residues)
MLRWLRDFVL PTAACQDAEQ PTRYETLFQA LDRNGDGVVD IGELQEGLRN LGIPLGQDAE EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK NNDGKIEASE IVQSLQTLGL TISEQQAELI LQSIDVDGTM TVDWNEWRDY FLFNPVTDIE EIIRFWKHST GIDIGDSLTI PDEFTEDEKK SGQWWRQLLA GGIAGAVSRT STAPLDRLKI MMQVHGSKSD KMNIFGGFRQ MVKEGGIRSL WRGNGTNVIK IAPETAVKFW AYEQYKKLLT EEGQKIGTFE RFISGSMAGA TAQTFIYPME VMKTRLAVGK TGQYSGIYDC AKKILKHEGL GAFYKGYVPN LLGIIPYAGI DLAVYELLKS YWLDNFAKDS VNPGVMVLLG CGALSSTCGQ LASYPLALVR TRMQAQAMLE GSPQLNMVGL FRRIISKEGI PGLYRGITPN FMKVLPAVGI SYVVYENMKQ TLGVTQK
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